Verily, COVID-19 has become today’s super-villain, but it has not checked our real-life heroes from doing their job and tirelessly working to find ways to combat the threat and eventually beat the invisible archenemy. They are the medical practitioners— laboratory scientists, doctors, nurses, medical technologists, vascular specialists, internists, cardiologists, among others—as well as health care support workers such as orderlies and phlebotomists, direct care workers like home health and personal care aides, health care service workers like housekeepers and cooks as well as those who pick up the trash. Going to work during this COVID-19 pandemic—now for 13 months of various stages of lockdown in this country—has placed frontline workers under immense and unprecedented pressure, putting their physical, mental and social well-being at risk. Exposure to excessive stress for prolonged periods can have many harmful consequences on the emotional and mental well-being of frontline workers. Undoubtedly this intemperate scenario, which has infected and killed in both an aggregate hundreds of thousands, the scores of thousands of recoveries notwithstanding, can lead—in fact it has—to burnout. It has triggered the onset of common mental disorders like depression and anxiety or post-traumatic stress disorder.